Import of proteins into mitochondria
- 31 May 1988
- journal article
- research article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 319 (1193) , 121-126
- https://doi.org/10.1098/rstb.1988.0036
Abstract
A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across the mitochondrial membranes. During post-translational import, this unfolding process appears to be a major rate-limiting step. It can be blocked by ligands that stabilize the protein’s native conformation and appears to be accompanied by the cleavage of ATP outside the mitochondrial inner membrane.This publication has 23 references indexed in Scilit:
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