Immunochemotherapy for Murine Bladder Tumor with a New Human Recombinant Tumor Necrosis Factor (rTNF-S), VP-16 and Hyperthermia
- 1 August 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 142 (2 Part 1) , 386-389
- https://doi.org/10.1016/s0022-5347(17)38770-0
Abstract
Effects of a new recombinant human tumor necrosis factor (rTNF-S) on the growth of murine bladder tumor (MBT-2) were studied. The growth of MBT-2 was significantly inhibited by intratumor injection of rTNF-S. Moreover etoposide (VP-16) and hyperthermia at relatively low temperature enhanced the antitumor effect of rTNF-S. Since TNF is considered to have species preference, these observations may be relevant to treatments for human bladder tumor with human TNF.This publication has 16 references indexed in Scilit:
- Improvement of cytotoxicity of tumor necorosis factor (TNF) by increase in basicity of its N-terminal regionBiochemical and Biophysical Research Communications, 1987
- Phase I clinical trial of recombinant human tumor necrosis factorCancer Chemotherapy and Pharmacology, 1987
- Combination tumor-immunotherapy with recombinant tumor necrosis factor and recombinant interleukin 2 in miceInternational Journal of Cancer, 1987
- Tumor Necrosis Factor Enhances the in Vitro and in Vivo Efficacy of Chemotherapeutic Drugs Targeted at DNA Topoisomerase II in the Treatment of Murine Bladder CancerJournal of Urology, 1987
- Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in VitroScience, 1985
- Human tumor necrosis factor. Production, purification, and characterization.Journal of Biological Chemistry, 1985
- Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxinNature, 1984
- An endotoxin-induced serum factor that causes necrosis of tumors.Proceedings of the National Academy of Sciences, 1975
- A generalized Wilcoxon test for comparing arbitrarily singly-censored samplesBiometrika, 1965