The Development of Amyloid β Protein Deposits in the Aged Brain
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- 8 March 2006
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science of Aging Knowledge Environment
- Vol. 2006 (6) , re1
- https://doi.org/10.1126/sageke.2006.6.re1
Abstract
The deposition of amyloid protein (A) in the human brain and the generation of neurofibrillary tangles are the histopathological hallmarks of Alzheimer's disease. Accumulation of A takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between A production and clearance. This Review describes the different types of A deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in A deposition. The role of intracellular A in A deposition and the mechanism of A toxicity are also discussed.Keywords
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