Synthesis of 1-(Phosphonomethoxyalkoxy)pyrimidines, a Novel Series of Acyclonucleotide Analogues
- 1 January 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1991 (11) , 947-950
- https://doi.org/10.1055/s-1991-26614
Abstract
A convenient synthesis of 1-(2-phosphonomethoxyalkoxy)uracil and -thymine derivatives, 4-7 by Mitsunobu coupling of 1-hydroxypyrimidines with suitably functionalized alcohols is described. The uracil analogues were converted to the corresponding 1-(phosphonomethoxyalkoxy)cytosines 8,9 via intermediate 4-(1,2,4-triazol-1-yl) derivatives. The antiviral activity of this series of compounds is reported.Keywords
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