A regioselective synthesis of 3,5-disubstituted isoxazoles
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 67-72
- https://doi.org/10.1039/p19860000067
Abstract
The 3-aryl-5- and 5-aryl-3-(phenylsulphonylmethyl)isoxazoles (6) and (9) respectively were regio-selectively prepared from 1-aryl-3-methylthio-4-phenylsulphonylbut-2-en-1-one (1). As an application of the present method, 3-methyl-5-(4-pyridyl)isoxazole (2) was also synthesized from compound (1). The reaction of compound (1) with guanidine led to 2-amino-4-phenyl-6-(phenylsulphonylmethyl)-pyrimidine (3).This publication has 1 reference indexed in Scilit:
- Isoxazole anthelminticsJournal of Medicinal Chemistry, 1977