SUCCINOXIDASE ACTIVITY AND COENZYME A CONCENTRATION IN HORMONE STIMULATED MAMMARY GLANDS OF OVARIECTOMIZED GUINEA PIGS1

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Abstract
The proliferation and functioning of the parenchymatous tissue of the mammary gland is known to involve the combined activity of several endocrine secretions. The experimental development of mammary glands in both males and females of various species has been extensively investigated (Scharf and Lyons, 1941; Mixner and Turner, 1942; Kirkham and Turner, 1954). Turner and Gomez (1934) stimulated male and immature castrate female guinea pigs with estrogens for 20 days, finding very evident growth and development both in extent and thickness of the mammary glands. Nelson (1936), using various concentrations of estrogens obtained corresponding results. Jeffers (1935), as the result of her cytological studies of the mammary glands of pseudopregnant rats, has expressed the opinion that such glands could have supported lactation comparable to that occurring after normal birth. Inasmuch as previous studies have only measured the attainment of full mammary growth by the occurrence of milk secretion or by cytological examination upon removal of estrogen influence in non-pregnant animals,