Abstract
We developed a new endoscopic technique, the endoscopic full-thickness resection (EFTR) and endoscopic complete defect closure (ECDC), for the treatment of early gastrointestinal malignancies. Two rectal and one duodenal carcinoid were treated by EFTR with ECDC and resectability, complications and pathological findings were evaluated. In all cases, the lesion was completely resected without serious complications. The histology of the specimen also confirmed complete resection of the tumor. This technique has great potential for the treatment of early gastrointestinal malignancies. Preliminary results have shown that early malignant gastrointestinal lesions can be safely and completely resected by EFTR with ECDC.

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