THE BENEFICIAL EFFECT OF DILTIAZEM ON EXERCISE-INDUCED ST DEPRESSION, MEASURED BY BODY-SURFACE MAPPING, IN STABLE EFFORT ANGINA-PECTORIS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 5  (1) , 49-60
Abstract
The effect of diltiazem, a Ca antagonist, was examined in 8 male patients with stable effort angina pectoris by means of multistage treadmill testing using body surface mapping. The area and severity of exercise-induced ST depression after 90 mg of diltiazem administered orally 3 h before exercise were compared with those without diltiazem. Although the same workload was performed, the area and severity of exercise-induced ST depression were significantly diminished (P < 0.005) after diltiazem. The reproducibility of these observations was confirmed in 2 of the 8 patients studied and in 3 other patients. Because exercise-induced ST depression in patients with coronary artery disease is generally believed to reflect myocardial ischemia, diltiazem may be able to reduce the exercise-induced myocardial ischemia in effort angina pectoris.

This publication has 0 references indexed in Scilit: