A New Sulfonamide Resistance Gene ( sul3 ) in Escherichia coli Is Widespread in the Pig Population of Switzerland
- 1 March 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (3) , 1169-1172
- https://doi.org/10.1128/aac.47.3.1169-1172.2003
Abstract
A new gene, sul3 , which specifies a 263-amino-acid protein similar to a dihydropteroate synthase encoded by the 54-kb conjugative plasmid pVP440 from Escherichia coli was characterized. Expression of the cloned sul3 gene conferred resistance to sulfamethoxazole on E. coli . Two copies of the insertion element IS 15 Δ /26 flanked the region containing sul3 . The sul3 gene was detected in one-third of the sulfonamide-resistant pathogenic E. coli isolates from pigs in Switzerland.Keywords
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