Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1
Open Access
- 8 June 2007
- journal article
- research article
- Published by Springer Nature in BMC Genomic Data
- Vol. 8 (1) , 31
- https://doi.org/10.1186/1471-2156-8-31
Abstract
Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes. Functional assignments of archaeal DNA replication genes have been primarily based upon sequence homology and biochemical studies of replisome components, but few genetic studies have been conducted thus far. We have developed a tractable genetic system for knockout analysis of genes in the model halophilic archaeon, Halobacterium sp. NRC-1, and used it to determine which DNA replication genes are essential.Keywords
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