BRAIN DOPAMINE AND SEIZURE SUSCEPTIBILITY IN MICE

Google Scholar
  • 1 January 1978
    • journal article
    • research article
    • Vol. 30  (4) , 513-519
Abstract
In electroshock test apomorphine appeared without effect, D,L-amphetamine and L-dopa (in a high dose) elevated the convulsive threshold, while amantadine decreased it. Among investigated dopamine (DA) receptor blockers spiperone, pimozide and fluphenazine lowered the threshold, haloperidol being without effect. The convulsive threshold elevated by L-dopa was not affected by neuroleptics and phentolamine but DA receptor blockers and phentolamine antagonized the effect of D,L-amphetamine. The effect of amantadine was not influenced by neuroleptics. In pentylenetetrazole (PTZ) test only amantadine and L-dopa (in high doses) affected the threshold, increasing seizure susceptibility; the above effect was not abolished by pimozide. The activity of brain DA system seems not to be involved directly in the susceptibility to electrogenic or PTZ-induced seizures in mice.