Effects of saikosaponins on the metabolic actions of adrenaline, ACTH and insulin on the fat cells.

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Abstract
Saikosaponins a and d inhibited adrenaline[epinephrine A]-induced lipolysis in fat cells isolated from epididymal adipose tissue of rats. Saikosaponins a, b1, b2, b4, c and d inhibited ACTH-induced lipolysis in the fat cells. Insulin-stimulated lipogenesis in adipose tissue was significantly reduced by saikosaponin d. Propranolol (a .beta.-blocker) inhibited not only lipolytic actions induced by A and ACTH but lipogenesis stimulated by insulin. Saikosaponins b1, b2, b4 and c selectively inhibited ACTH-induced lipolysis without affecting the lipogenetic effect of insulin. The structure-activity relationship of saikosaponins derived from Bupleurum falcatum is discussed.

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