Gene Therapy for Cardiovascular Diseases
- 1 January 1996
- journal article
- review article
- Published by Taylor & Francis in Annals of Medicine
- Vol. 28 (2) , 89-94
- https://doi.org/10.3109/07853899609092931
Abstract
Gene therapy offers a promising alternative for the treatment of various cardiovascular diseases. Blood vessels are among the easiest targets for gene therapy and in some pathological conditions only a temporary expression of the transfected gene will be required to achieve a beneficial biological effect. These conditions include the prevention of postangioplasty restenosis, postbypass atherosclerosis, peripheral atherosclerotic vascular disease and thrombus formation. Further developments in gene transfer vectors and gene delivery techniques are required before a full therapeutic potential of gene therapy in cardiovascular diseases can be evaluated.Keywords
This publication has 22 references indexed in Scilit:
- A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.Proceedings of the National Academy of Sciences, 1995
- Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivoNature Medicine, 1995
- Gene Therapy for Vascular Smooth Muscle Cell Proliferation After Arterial InjuryScience, 1994
- Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides.Journal of Clinical Investigation, 1994
- HUMAN GENE THERAPYAnnual Review of Biochemistry, 1993
- The Basic Science of Gene TherapyScience, 1993
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivoNature, 1992
- Human gene therapy comes of ageNature, 1992
- Approaches to Gene Therapy of Complex Multigenic Diseases: Cancer as a Model and Implications for Cardiovascular Disease and DiabetesAnnals of Medicine, 1992