Thermotropic behavior of some fluorodimyristoylphosphatidylcholines.
- 1 May 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (5) , 2239-2243
- https://doi.org/10.1073/pnas.76.5.2239
Abstract
The thermotropic behavior of (X,X-difluoromyristoyl)phosphatidylcholines with X = 4, 8 or 12 was studied by high sensitivity differential scanning calorimetry. The compound with X = 4 has a higher transition temperature than dimyristoylphosphatidylcholine, the others have lower values. All 3 lipids have transition enthalpies approximately twice that of the unsubstituted lipid. The substituted lipids form strikingly nonideal mixtures with the parent compound. Results obtained using these or related compounds as probes of bilayer or membrane behavior must be interpreted cautiously. Some of the properties exhibited by geminal F atoms in fluorinated phospholipids resemble those of cis double bonds in lipids.This publication has 11 references indexed in Scilit:
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