Left Ventricular Filling Profiles in Young White-Coat Hypertensive Patients Without Hypertrophy

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Abstract
This study was to assess left ventricular diastolic function in young white-coat hypertensive subjects P <.001, P <.001, P= .002, and P <.001, respectively). No difference was noticed between white-coat and sustained hypertensives. Compared with normotensives, white-coat hypertensives had higher values of plasma and urine norepinephrine ( P <.001 and P <.001, respectively), plasma and urine aldosterone ( P <.001 and P= .002, respectively), plasma renin activity ( P =.04), total cholesterol ( P =.001), and LDL cholesterol ( P <.001). No difference was observed between white-coat and sustained hypertensives. Within white-coat hypertensives, 24-hour urinary aldosterone closely correlated with the ratio of late to early filling velocities ( P =.008), and plasma and 24-hour urinary norepinephrine correlated well with total cholesterol ( P =.037 and P= .006, respectively). No correlation was detected within the sustained hypertensives and normotensives. Heightened neurohumoral activity clearly supported the progression of diastolic dysfunction and metabolic abnormality in white-coat hypertensives.