The effect of free silica on the mucosal protective and antiflatulent properties of polydimethylsiloxane
- 1 November 1973
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 25 (11) , 859-863
- https://doi.org/10.1111/j.2042-7158.1973.tb09963.x
Abstract
The mucosal protective and antiflatulent properties of polydimethylsiloxane (PMS) alone, or containing free silica have been examined in rats. Both PMS and PMS + 6% silica significantly protected rat gastric mucosa from the irritant effects of aspirin but there was no significant difference between the protective effect of each agent. The antiflatulent property of PMS, as determined by X-ray measurements of foam production in the rat stomach, was significantly enhanced by the addition of free silica.Keywords
This publication has 3 references indexed in Scilit:
- An infrared study of the interaction between Aerosil-200 and polydimethylsiloxane (dimethicone-1000)Journal of Pharmacy and Pharmacology, 1973
- Use of Silicone in the Treatment of Intestinal Gas and BloatingPublished by American Medical Association (AMA) ,1960
- CHEMISORPTION VON ALKOHOLEN AN AMORPHEM SILICIUMDIOXYDEuropean Journal of Organic Chemistry, 1957