TREATMENT OF ARTERIAL-HYPERTENSION WITH NIFEDIPINE IN PATIENTS WITH CHRONIC RENAL-INSUFFICIENCY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 23  (1) , 41-45
Abstract
The acute and chronic antihypertensive effects of nifedipine were investigated in patients with chronic renal insufficiency (CRI). The acute effects were assessed after the administration either of a fast-release nifedipine capsule or a slow-release nifedipine tablet in 10 and 15 patients, respectively. Both the preparations induced prompt and marked reduction of systolic and of diastolic blood pressure; the capsules showed a shorter antihypertensive effect (2 h) than tablets (> 6 h). The chronic effects of nifedipine tablets given in addition to the previous therapy was assessed in 25 patients with CRI and resistant hypertension. Both systolic and diastolic blood pressure values promptly fell and maintained within the normal range over the whole period of the study (12 mo.).