Effect of Re-Conpression on the Properties of Tablets Prepared by Dry Granulation

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Abstract
The effect of re-compression on the tableting properties of some direct compression excipients (directly compressible starch, dicalcium phosphate dihydrate and microcrystalline cellulose) and their formulations was examined. Re-compression generally reduced the tablet strength and this reduction was more significant when the initial compaction was carried out at a higher pressure. The reason for the reduction of tensile strength upon re-working is attributed to work hardening and the production of robust granules, which have increased resistance to deformation compared to unworked granules. This paper is based on a presentation made to the 31st National meeting of the Academy of Pharmaceutical Sciences, American Pharmaceutical Association, held at Orlando, Florida, U.S.A. on November 15-19th, 1981.