Studies on diffusing factors

Publisher Website
Google Scholar
Abstract
Earlier work showed that aqueous extracts of mammalian testicle contain a factor that dramatically increases the permeability of tissues to injected fluids. No naturally occurring diffusing factor has been isolated. Hyaluronic acid, a muco-poly-saccharide obtained from the mucoproteins of vitreous humor and umbilical cord, is hydrolyzed, with a decrease in viscosity, by bacterial enzymes. This paper reports a detailed study of the association between the 2 properties[long dash]diffusion in tissues and hyaluronidase activity[long dash]in the case of testicular extracts, certain bacterial filtrates, and snake venom. The exptl. results support the belief that diffusion in the skin is due to hyaluronidase activity.