Evidence for a T-cell reaction in the cutaneous sarcoid granuloma
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 259 (2) , 135-140
- https://doi.org/10.1007/bf00557953
Abstract
In cutaneous sarcoidosis, mononuclear cells of granuloma have been freed and characterized by immunological tests. Of these cells, 84% of them were found to be T dependent by the E rosette test. A similar value (79%) was obtained in the stroma of delayed hypersensitivity reaction, whose immunological functions are well known. However, the physiological role of the thymus dependent pupulation within granulomas must be established. Mononukleare Zellen von Granulomen bei cutaner Sarkoidose wurden isoliert und durch immunologische Tests charakterisiert. 84% dieser Zellen wurden durch den Rosettentest den T-Zellen zugeordnet. Ein etwa gleicher Prozentsatz (79%) wurde im Gewebe mit allergischer Spätreaktion beobachtet, deren immunologische Typisierung und Funktion gut bekannt ist. Die Rolle der thymusabhängigen Zellpopulation in Granulomen bedarf jedoch weiterer Untersuchungen.Keywords
This publication has 14 references indexed in Scilit:
- MORPHOLOGY AND DISTRIBUTION OF THE CELLS OF A SARCOID GRANULOMA: ULTRASTRUCTURAL STUDY OF SERIAL SECTIONSAnnals of the New York Academy of Sciences, 1976
- IMMUNOLOGICAL IDENTIFICATION OF SUBPOPULATIONS OF MONONUCLEAR CELLS IN SARCOID GRANULOMASAnnals of the New York Academy of Sciences, 1976
- SARCOID LYMPHOCYTES: B‐ AND T‐CELL QUANTITATIONAnnals of the New York Academy of Sciences, 1976
- Peripheral blood lymphocyte subpopulations in sarcoidosisCellular Immunology, 1975
- Effect of Sera from Patients with Sarcoidosis on in vitro Lymphocyte ResponseInternational Archives of Allergy and Immunology, 1974
- The Human Rosette-Forming Cell as a Marker of a Population of Thymus-Derived CellsJournal of Clinical Investigation, 1972
- A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTESThe Journal of Experimental Medicine, 1972
- A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXESThe Journal of Experimental Medicine, 1970
- RECEPTORS FOR COMPLEMENT ON LEUKOCYTESThe Journal of Experimental Medicine, 1968
- Significance and Specificity of the Kveim Reaction1Acta Medica Scandinavica, 1964