COMPARATIVE EVALUATION OF FATTY-ACIDS LABELED WITH C-11, CL-34M, BR-77, AND I-123 FOR METABOLIC STUDIES OF MYOCARDIUM
- 1 January 1978
- journal article
- research article
- Vol. 19 (3) , 298-302
Abstract
Various long-chain fatty acids were labeled with 11C, 34mCl, 77Br, and 123I and evaluated for their potential application in measuring myocardial metabolism in vivo. Comparative studies of the kinetics of accumulation and clearance from the heart muscle of mice indicate that the extraction of .omega.-halofatty acids is more efficient than that of .alpha.-halofatty acids. Among the .omega.-halofatty acids, the highest uptake is observed for the 17-iodoheptadecanoic acid, which shows an extraction behavior almost identical to that of [1-11C] palmitic acid, although with a higher radioactivity level in blood due to the release of free iodide.This publication has 5 references indexed in Scilit:
- Carbon-11 and radiopharmaceuticalsThe International Journal of Applied Radiation and Isotopes, 1977
- External detection and visualization of myocardial ischemia with 11C-substrates in vitro and in vivo.Circulation Research, 1976
- EXPERIMENTAL BASIS FOR MYOCARDIAL IMAGING WITH I-123-LABELED HEXADECENOIC ACID1976
- Use of Radioiodinated Fatty Acid for Photoscans of the HeartCirculation Research, 1965
- MYOCARDIAL METABOLISM OF FATTY ACIDS*Journal of Clinical Investigation, 1960