Experimental Cerebral Aneurysms

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Abstract
Experimentally induced cerebral aneurysms in rats treated with unilateral ligation of the common carotid artery, deoxycorticosterone and salt hypertension, and β-aminopropionitrile (BAPN) have many similarities to spontaneous lesions in man in respect to the location, relation to the arterial fork and histological findings. For the convenience of further studies, experimental conditions were reanalized. Male, adult SD rats were divided into four groups by different combinations of these three treatments. Cerebral aneurysms developed in rats treated with unilateral ligation of the common carotid artery and experimental hypertension with or without BAPN. Aneurysms developed more frequently in rats with BAPN than in those without BAPN. Aneurysms in these two groups were located on the anterior cerebral-anterior communicating arterial complex and on the proximal segment of the posterior cerebral artery on the side of carotid ligation. Aneurysms were found neither in rats treated with hypertension and BAPN nor in rats with carotid ligation and BAPN. The results show that unilateral ligation of the carotid artery with hypertension is the minimal requirement for inducing cerebral aneurysms. BAPN increases the incidence of aneurysms. Furthermore, carotid ligation provides the site of aneurysms. It may be postulated that hypertension predisposes aneuirysmal formation chiefly with vascular changes caused by hypertension, such as increased permeability, but not with increased intraluminal pressure.

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