Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents
- 1 July 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (7) , 885-890
- https://doi.org/10.1021/jm00217a003
Abstract
A series of 5-substituted and 2,5-disubstituted 1,3-dioxanes was synthesized and evaluated for analgesic activity in mice and rats. Some of the compounds possessed significant analgesic effects; their structure-activity relationships and chemistry were discussed. These compounds represent a unique series of analgesic agents.This publication has 1 reference indexed in Scilit:
- TheKnoevenagel CondensationPublished by Wiley ,2011