Enantioselectivity of Epoxide Formation from Halohydrins by Means of Flavobacterium Rigense
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in Biocatalysis
- Vol. 10 (1-4) , 159-168
- https://doi.org/10.3109/10242429409065226
Abstract
The formation of epoxides from several halohydrins was achieved using resting cells from Flavobacterium rigense. The reaction showed a high substrate specificity for halohydrins with a terminal halogen atom but only low enantioselectivity (12–58% e.e.). The epoxides always had the (S)-configuration. Substrates which in the halogen atom was replaced by another leaving group (-O-SO2CH3, -O-Tos, -N3) were not accepted. An attempt to improve the enantioselectivity by using a two phase system consisting of an aqueous and an organic solvent phase was not successful.Keywords
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