THE RELATION BETWEEN ACUTE TOXICITY AND CRITICAL RATE OF DISPOSAL OF SEVERAL LOCAL ANESTHETICS

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Abstract
The maximum rate at which several local anesthetics may be administered intravenously and just fail to elicit clonic convulsions in unanesthetized rabbits has been compared to the acute LD50's reported in the literature. The exceptionally good agreement between the two sets of data suggests that the processes which remove active drug molecules from the blood operate equally well at high and low rates of administration.