Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya.
- 1 January 1986
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 39 (2) , 259-265
- https://doi.org/10.7164/antibiotics.39.259
Abstract
An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate. THX was subsequently identified as one of the four possible stereoisomers of 4-fluorothreonine. Inorganic fluoride or any one of a number of organofluorine compounds can be used as precursors of 4-fluorothreonine. In addition, 19F NMR has provided evidence that the organism synthesizes fluoroacetate under the same fermentation conditions. The in vitro antibacterial spectrum of 4-fluorothreonine is also presented.This publication has 3 references indexed in Scilit:
- Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya.Journal of Biological Chemistry, 1985
- Thienamycin, a new .BETA.-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.The Journal of Antibiotics, 1979
- The accumulation of fluoroacetate and fluorocitrate in forage crops collected near a phosphate plantAtmospheric Environment (1967), 1968