A Prospective Study of Dextran-induced Anaphylactoid Reactions in 5745 Patients
Open Access
- 1 May 1987
- journal article
- research article
- Published by SAGE Publications in Anaesthesia and Intensive Care
- Vol. 15 (2) , 163-167
- https://doi.org/10.1177/0310057x8701500208
Abstract
A prospective study of dextran-induced anaphylactoid reactions (DIAR) in 5745 gynaecological and obstetric patients who received dextran 70 solution intravenously while undergoing major surgery revealed 8 patients who had Grade I or II reactions and 7 patients who had Grade III or IV reactions. The incidence of severe reactions was 1:821 patients treated. The overall incidence of reactions per patient treated was 1:383. One neonatal death followed a dextran-induced cardiac arrest in a woman about to undergo caesarean section. The risks of dextran 70 treatment exceeded the risks of thromboembolism in these patients.Keywords
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