Substance P‐like immunoreactivity is reduced in Alzheimer's disease cerebral cortex
- 30 June 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (7) , 1205
- https://doi.org/10.1212/wnl.37.7.1205
Abstract
Substance P is an undecapeptide which has been found in human cortical neurons. We measured concentrations of this peptide in Alzheimer's disease (AD) and control postmortem tissue by radioimmunoassay. Using high-performance liquid chromatography, most of the immunoreactivity from AD or control temporal cortex comigrated with synthetic standards. Significant reductions of 20 to 40% in substance P-like immunoreactivity were found in AD cerebral cortex and hippocampus, most severe in the inferior temporal gyrus. Substance P neurons or their terminals are vulnerable to the pathophysiologic process in AD.This publication has 20 references indexed in Scilit:
- Thyrotropin-releasing hormone, luteinizing hormone-releasing hormone and substance P immuno-reactivity in post-mortem brain from cases of alzheimer-type dementia and Down's syndromeBrain Research, 1983
- Cortical Substance P‐Like Immunoreactivity in Cases of Alzheimer's Disease and Senile Dementia of the Alzheimer TypeJournal of Neurochemistry, 1982
- The regional distribution of somatostatin, substance P and neurotensin in human brainBrain Research, 1981
- Organization of substance P fibers within the hippocampal formation demonstrated with a biotin-avidin immunoperoxidase techniqueJournal of Comparative Neurology, 1981
- A substance P projection to the hippocampusBrain Research, 1981
- Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer typeNeurobiology of Aging, 1981
- Nerve growth factor stimulates the development of substance P in sensory ganglia.Proceedings of the National Academy of Sciences, 1980
- Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminalsNeuroscience, 1978
- The distribution of substance P immunoreactive fibers in the rat central nervous systemJournal of Comparative Neurology, 1978
- The substance P projections to the frontal cortex and the substantia nigraNeuroscience Letters, 1978