Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
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- 8 July 2003
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 100 (15) , 8987-8992
- https://doi.org/10.1073/pnas.1432926100
Abstract
Calcineurin (CN), a calcium- and calmodulin-dependent protein phosphatase, plays a significant role in the central nervous system. Previously, we reported that forebrain-specific CN knockout mice (CN mutant mice) have impaired working memory. To further analyze the behavioral effects of CN deficiency, we subjected CN mutant mice to a comprehensive behavioral test battery. Mutant mice showed increased locomotor activity, decreased social interaction, and impairments in prepulse inhibition and latent inhibition. In addition, CN mutant mice displayed an increased response to the locomotor stimulating effects of MK-801. Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis.Keywords
This publication has 47 references indexed in Scilit:
- Pharmacological Agents That Directly Modulate Insulin SecretionPharmacological Reviews, 2003
- Glutamatergic Mechanisms in SchizophreniaAnnual Review of Pharmacology and Toxicology, 2002
- In Vitro Cytokine Secretion in Individuals with Schizophrenia: Results, Confounding Factors, and Implications for Further ResearchBrain, Behavior, and Immunity, 2001
- Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like MemoryCell, 2001
- Interactions Between Monoamines, Glutamate, and GABA in Schizophrenia: New EvidenceAnnual Review of Pharmacology and Toxicology, 2001
- Calcium, Calcineurin, and the Control of TranscriptionJournal of Biological Chemistry, 2001
- Beyond the Dopamine ReceptorPublished by Elsevier ,1999
- Behavioral Phenotyping of Transgenic and Knockout MicePublished by Taylor & Francis ,1999
- Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implicationsLife Sciences, 1997
- Central Nervous System Toxicity after Liver TransplantationNew England Journal of Medicine, 1987