THE TOLERANCE OF MALE AND FEMALE MICE RESPECTIVELY TO ESTROGENS AND ANDROGENS1

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Abstract
Each sex of the Little dba mice was better able to tolerate the "sex hormone" of the opposite sex. Testosterone propionate in daily doses of 0.4 mg. and 0.20 mg. was not fatal but caused a decrease in gain of body wt. in the [male][male]. Estradiol dipropionate in doses of 0.25 and 0.10 mg. per day was fatal but more so in the [female][female] than the [male][male] Testosterone propionate added to the latter in 4 times its quantity was able to nullify in part but not completely the fatally toxic properties of the estrogen. Testosterone propionate caused a definite and striking loss of hair in the [male] mice and only a slight effect in [female][female]. The controls showed no effect.