Effect of Beta-Casomorphin and Its Analogue on Serum Prolactin in the Rat
- 1 April 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 85 (02) , 249-252
- https://doi.org/10.1055/s-0029-1210445
Abstract
The effects of exogenous opioid peptides beta-casomorphin Tyr-Pro-Phe-Pro-Gly-Pro-Ile and its analogue Tyr-Pro-Gly-Pro-Phe-Pro-Ile (analogue I) were found to increase proiactin level in plasma after intraperitoneal injection. Analogue I was more potent. This effect of beta-casomorphin and analogue I were blocked by an opioid antagonist, naloxone. These results indicate that the exogenous opioid peptides (exorphins) may participate in the regulation of proiactin secretion. The similarity of analogue I with enkephalin structure was discussed.Keywords
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