The Endothelium of the High Endothelial Venule: A Specialized Endothelium with Unique Properties
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Pathobiology
- Vol. 55 (1) , 1-10
- https://doi.org/10.1159/000163388
Abstract
High endothelial venules (HEV) in lymphoid organs are specialized to facilitate the passage of lymphocytes into lymphoid parenchyma. This is accomplished by a ligand-receptor system on the endothelium and lymphocytes, which differs between lymph nodes and Peyer’s patch. Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local microenvironments.Keywords
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