Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
- 1 September 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 371 (6496) , 389-395
- https://doi.org/10.1038/371389a0
Abstract
Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective exclusion of self-antigen-binding B cells from the normal migration route into lymphoid follicles, resulting in their premature death. This is a striking example of homeostasis by cellular competition for limiting niches and may explain the paradoxical association between immunodeficiency and autoimmunity.Keywords
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