Effect of isosorbide dinitrate, verapamil, and labetalol on portal pressure in cirrhosis.
- 31 August 1985
- Vol. 291 (6495) , 561-562
- https://doi.org/10.1136/bmj.291.6495.561
Abstract
The effects on portal pressure of the vasodilatory drugs isosorbide dinitrate and verapamil and of an alpha and beta blocking agent, labetalol, were assessed in 21 patients with cirrhosis and portal hypertension. The wedged hepatic venous pressure gradient (wedged minus free hepatic venous pressures) was used as an index of portal pressure and was not significantly changed by treatment with labetalol (n = 5) but was significantly decreased by verapamil (n = 6; p less than 0.05) and isosorbide dinitrate (n = 10; p less than 0.01). Long term administration of isosorbide dinitrate also had a significant effect (p less than 0.01).This publication has 4 references indexed in Scilit:
- A Randomized Controlled Study of Propranolol for Prevention of Recurrent Gastrointestinal Bleeding in Patients with Cirrhosis: A Final ReportHepatology, 1984
- Controlled Trial of Propranolol for the Prevention of Recurrent Variceal Hemorrhage in Patients with CirrhosisNew England Journal of Medicine, 1983
- Treatment of portal hypertension with isosorbide dinitrate alone and in combination with vasopressinCritical Care Medicine, 1983
- Nitroglycerin Improves the Hemodynamic Response to Vasopressin in Portal HypertensionHepatology, 1982