Hypertension associated with massive, bilateral, posture-dependent renal dysfunction.

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Abstract
Hippurate function scintiscans were obtained in prone and standing positions from a group of 76 patients with concurrent hypertension and nephroptosis. Of these patients, 12 had massive, bilateral disturbance of intrarenal hippurate transport in the standing position; hippurate transport was normal in the prone position. This pattern was present in only 3 of 120 normotensive patients with nephroptosis. To investigate the importance of nephroptosis, 87 other hypertensive patients were examined. Of these patients, 18 demonstrated posture-dependent tubular dysfunction, but only 4 had nephroptosis. A direct relationship between bilateral posture-dependent tubular dysfunction and hypertension is suggested.