INFLUENCE OF VENOUS RETURN ON CARDIAC MECHANICAL AND SARCOPLASMIC-RETICULUM FUNCTION DURING ENDOTOXEMIA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 4  (2) , 143-152
Abstract
Escherichia coli endotoxin (0.03 mg/ml) added to blood perfusing a [dog] heart-lung preparation with a venous return of 600 ml/min produced a significant depression in ventricular function within 4 h. Fragmented sarcoplasmic reticulum isolated from the myocardium of the endotoxin-perfused heart-lung preparations showed depressed Ca uptake rates and ATPase activity. When venous return was increased to 1200 ml/min, gram-negative endotoxin had no effect on ventricular function, isolated fragmented sarcoplasmic reticulum Ca uptake, or ATPase activity. Gram-negative endotoxin or a product thereof may act in synergism with low venous return in order to depress myocardial function.

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