Oligohydramnios associated with prostaglandin synthetase inhibitors in preterm labour

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Abstract
Summary. The use of prostaglandin synthetase inhibitors (indomethacin and ibuprofen) for >72 h in women with preterm labour (n=67) was significantly (Pn=67). Oligohydramnios developed in 26 of 37 women (70%) treated with indomethacin and 8 of 30 women treated with ibuprofen (27%) (P<0.01). Oligohydramnios developed in only two control subjects and one of these pregnancies was associated with intrauterine growth retardation. All 34 cases of oligohydramnios in the treatment group resolved after stopping medication, whereas the two in the control group did not resolve. No instances of renal failure, premature closure of the ductus arteriosus, pulmonary hypertension, or bleeding disorders were noted in any of the treated or control infants.