Palladium-Catalyzed Approach to 5-Substituted Uracil and Uridine Derivatives

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Abstract
A new coupling procedure between 5-iodouracil and unsaturated tributylstannanes, to give 5-(1-alkenyl)-, 5-(2-phenyl-ethynyl)- and 5-(4-methoxyphenyl)uracils, is described. The reaction was optimized with respect to the palladium ligand, whereby tri(2-furyl)phosphine, together with triphenylarsine, were found to be the best ligands. This coupling can be extended to uridine derivatives.

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