Suppressing Hepatitis B without Resistance — So Far, So Good

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Abstract
Clinicians caring for patients with chronic viral hepatitis face complex challenges. The ultimate goal of therapy for chronic hepatitis is to heal hepatic inflammation and necrosis, thereby halting progression to cirrhosis and hepatocellular carcinoma. Although our understanding of the mechanisms of liver injury, fibrosis, regeneration, and repair is incomplete, it is apparent that the key to successful therapy for chronic viral hepatitis is the durable suppression of viral replication. Potential approaches using antifibrotic, cytoprotective, or proregenerative agents will remain secondary to the use of drugs that directly inhibit viral replication. Effective long-term suppression of viral replication requires medications that are . . .