OOGENESIS AND ITS RELATION TO THE OESTROUS CYCLE IN THE ADULT MOUSE

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Abstract
It is now evident, at least in those species which have been closely studied, that new crops of oogonia are produced cyclically by the ovaries of adult vertebrates, and that the old theory of the laying down of an irreplaceable stock of young eggs during embryonic life must be abandoned. In the lower vertebrates these facts have been accepted for some time, although there has been some mystification concerning the source and mode of origin of the new eggs. Wheeler [1924] suggested that in the dab, Pleuronectes limanda L., they were produced after each breeding season from the cells of the collapsed follicles, but it seems, as in the minnow, Phoxinus laevis L. [Bullough, 1942a], that it is the common condition for new oogonia to arise from the mitotic divisions of the cells of the germinal epithelium investing the ovary. In the warm-blooded vertebrates the fact that new eggs

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