Expression of intercellular adhesion molecule‐1 (ICAM‐1) on renal‐cell cancer: Possible significance in host immune responses

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Abstract
In this study we examined the expression of intercellular adhesion molecule-1 (ICAM-I) in 28 cases of renal-cell cancer (RCC). We also examined ICAM-I expression on RCC cell lines in response to cytokines. Immunohistochemistry revealed frequent expression (23 positive cases among the 28 RCCs) of ICAM-I in RCC. The molecule was not detected on renal tubular cells as far as could be determined. Furthermore, the number of ICAM-I-positive cells in RCC was significantly correlated with the degree of mononuclear cell infiltration, involving mainly T lymphocytes and a smaller number of macrophages bearing the LFA-I molecule. Expression of ICAM-I on RCC cell lines was augmented by in vitro treatment with interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin-I (IL-I)β. These results suggest that the expression of ICAM-I on RCC might be modified by cytokines produced by tumor-infiltrating mononuclear cells, and that ICAM-I expression on RCC might augment the host immune reaction.

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