6‐(substituted phenyl)‐5‐methyl‐4,5‐dihydro‐pyridazin‐3(2H)‐ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654
- 1 November 1988
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 25 (6) , 1689-1695
- https://doi.org/10.1002/jhet.5570250615
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-spiro[cycloalkane-1,3'-[3H]indol]-2'(1'H)-onesJournal of Medicinal Chemistry, 1987
- Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agentsJournal of Medicinal Chemistry, 1985
- A New Generation of Phosphodiesterase Inhibitors: Multiple Molecular Forms of Phosphodiesterase and the Potential for Drug SelectivityJournal of Medicinal Chemistry, 1985
- Selective reduction of pyridazin-3-ones and ring contraction to pyrrolidin-2-ones and 3-pyrrolin-2-onesJournal of the Chemical Society, Chemical Communications, 1984
- The use of α‐(aryl)‐4‐morpholineacetonitriles (masked acyl anion equivalents) in 1,4‐additions to α,β‐unsaturated esters and nitriles. A versatile synthetic route to 6‐aryl‐3(2H) pyridazinonesJournal of Heterocyclic Chemistry, 1978
- The chemistry of N‐cyanodithioimidocarbonic acid. III. An intermediate in heterocyclic synthesisJournal of Heterocyclic Chemistry, 1975
- 6-(Substituted phenyl)-5-substituted-4,5-dihydro-3(2H)-pyridazinones. Antihypertensive agentsJournal of Medicinal Chemistry, 1974
- 6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. Series of hypotensive agentsJournal of Medicinal Chemistry, 1974
- General synthesis of 3-(substituted benzoyl)-3-substituted alkanoic acidsThe Journal of Organic Chemistry, 1973
- Heterocyclic synthesis from o-aminonitriles. XXX. Synthesis of some diazasteroidsThe Journal of Organic Chemistry, 1968