Prostaglandin E1Treatment in Experimental Acute Pancreatitis in the Rat
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 16 (5) , 265-273
- https://doi.org/10.1159/000128418
Abstract
Prostaglandin E1 (PGE1) was tested for cytoprotective activity against the development of experimental acute pancreatitis in the rat induced by the closed duodenal loop technique. Sham-operated, untreated and PGE1-treated pancreatitic rats were investigated. All rats received an initial bolus of 3 ml 5% dextrose in normal saline (D5NS) via jugular catheter 30 min prior to surgery, and a continuous subcutaneous infusion of 35 ml D5NS over 24 h. Each treated rat received 10 µg/kg PGEl· in the initial bolus and a maintenance dosage of 10 µg/kg/h via the infusate. Serum amylase rose significantly in all pancreatitic rats with no significant difference between treated and untreated. Pancreatic edema was more pronounced in PGE1-treated than in untreated rats. The ischemic and autolytic damage to acinar cells and vascular endothelial cells typical of untreated pancreatitis was delayed by PGE1. Mortality rates were unaffected by PGE1.Keywords
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