Pancreatic Beta-Cell Web: Its Possible Role in Insulin Secretion
- 10 March 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4026) , 1128-1130
- https://doi.org/10.1126/science.175.4026.1128
Abstract
A cortical band of fine microfilaments is consistently observed in the beta cells of the rat pancreas. Alteration of this cell web by cytochalasin B is associated with an enhancement of glucose-induced secretion of insulin by isolated islets. The microfilamentous web of the beta cell may play an important role in the emiocytosis of insulin secretory granules, by controlling their access to the cell membrane.Keywords
This publication has 12 references indexed in Scilit:
- MICROFILAMENTS AND CELL LOCOMOTIONThe Journal of cell biology, 1971
- The Stimulus-secretion Coupling of Glucose-induced Insulin Release: V. The Participation of a Microtubular-microfilamentous SystemDiabetes, 1971
- THE STIMULUS-SECRETION COUPLING OF GLUCOSE-INDUCED INSULIN RELEASEThe Journal of cell biology, 1971
- Microfilaments in Cellular and Developmental ProcessesScience, 1971
- Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. III. Uptake of45Calcium by Isolated Islets of Langerhans1Endocrinology, 1971
- Cytochalasin B: Effects upon Microfilaments Involved in Morphogenesis of Estrogen-Induced Glands of OviductProceedings of the National Academy of Sciences, 1970
- Effects of Cytochalasin B upon Microfilaments Involved in Morphogenesis of Salivary EpitheliumProceedings of the National Academy of Sciences, 1970
- New Hypothesis of Insulin SecretionNature, 1968
- Method for the Isolation of Intact Islets of Langerhans from the Rat PancreasDiabetes, 1967
- Structures Corresponding to Terminal Bars and Terminal Web in Many Types of CellsNature, 1960