Oral Gossypol in the Treatment of Patients with Refractory Metastatic Breast Cancer: A Phase I/II Clinical Trial
- 1 April 2001
- journal article
- clinical trial
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 66 (3) , 239-248
- https://doi.org/10.1023/a:1010686204736
Abstract
Gossypol has demonstrated in vitroeffects on cell cycle regulation and anti-tumor activity against mammary carcinoma cell lines. This Phase I/II study assesses both the effect of gossypol on cell...Keywords
This publication has 15 references indexed in Scilit:
- Gossypol Treatment of Recurrent Adult Malignant GliomasJournal of Neuro-Oncology, 1999
- Cyclin D1 in Breast CancerBreast Cancer Research and Treatment, 1998
- Antiproliferative activity of gossypol and gossypolone on human breast cancer cellsLife Sciences, 1995
- Redundant cyclin overexpression and gene amplification in breast cancer cells.Proceedings of the National Academy of Sciences, 1993
- RB and the cell cycle: Entrance or exit?Cell, 1989
- Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell linesGynecologic Oncology, 1989
- Structural Rearrangement of the Retinoblastoma Gene in Human Breast CarcinomaScience, 1988
- Inhibition of DNA polymerase α by gossypolBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1986
- Gossypol inhibits Ehrlich ascites tumor cell proliferationCancer Letters, 1984
- The determination of the number of patients required in a preliminary and a follow-up trial of a new chemotherapeutic agentJournal of Chronic Diseases, 1961