Urinary Loss of Clotting Factors Due to Hereditary Membranous Glomerulopathy
- 1 March 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 65 (3) , 376-383
- https://doi.org/10.1093/ajcp/65.3.376
Abstract
Severe plasma deficiencies of clotting factors IX and XII developed in a 59-year-old woman with a nephrotic syndrome secondary to a laminated membranous glomerulopathy. Both these clotting factors were subsequently identified in the patient’s urine. Chromatographic analysis of the urine revealed that the bulk of clotting activity attributed to factors IX and XII was in early eluting gel filtration fractions containing predominantly alpha-2 globulin and albumin. The unprecedented finding of two coagulation proteins in the urine is attributed to the marked proteinuria present in this case.Keywords
This publication has 3 references indexed in Scilit:
- Membranous GlomerulonephritisAnnals of Internal Medicine, 1973
- Acquired Factor IX Deficiency in the Nephrotic SyndromeAnnals of Internal Medicine, 1970
- Separation and Molecular Weight Estimation of Coagulation and Fibrinolytic Proteins by Sephadex Gel Filtration.Experimental Biology and Medicine, 1964