Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes

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Abstract
Intracellular Na concentrations and specific 3H-labeled glycoside binding characteristics were measured in the erythrocytes and leukocytes of patients with untreated essential hypertension. The results were compared with those in well-matched normotensive control subjects. Intracellular Na concentrations were increased in the leukocytes, but not in the erythrocytes, of patients with untreated essential hypertension. There were no differences in the 3H-labeled glycoside binding characteristics of either the erythrocytes or the leukocytes of hypertensive and normotensive subjects. There was no difference in the ability of plasma samples from hypertensive and normotensive subjects to inhibit the binding of [3H]-ouabain to intact leukocytes from normotensive subjects. These findings were not consistent with the presence of increased concentrations of a substance which behaved like a cardiac glycoside in the circulation of patients with untreated essential hypertension.