MEDULLARY CARCINOMA OF THE THYROID WITH ECTOPIC ACTH SYNDROME
- 1 September 1982
- journal article
- research article
- Published by Wiley in Acta Pathologica Japonica
- Vol. 32 (5) , 793-800
- https://doi.org/10.1111/j.1440-1827.1982.tb03193.x
Abstract
An autopsied patient with medullary carcinoma of the thyroid and ectopic ACTH syndrome is reported. A microadenoma of pancreatic islet coexisted in this case, which is assumed to be of D cell origin. Immunohistochemical study revealed decreased number of pituitary ACTH cells. Some of them showed Crooke''s degeneration. Hormone assay study of tumor tissue and plasma disclosed abnormal ACTH, .beta.-MSH and calcitonin. Somatostatin and Substance P were also demonstrated in tissue. Histologically the tumor showed solid alveolar pattern with a minor part consisting of small cell variant and this histologic variation is discussed.This publication has 15 references indexed in Scilit:
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