THE EFFECT OF SPLENIC CONTRACTION ON THE FORMED ELEMENTS OF THE BLOOD IN A CASE OF ANEMIA AND SPLENOMEGALY

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Abstract
In a patient who showed both anemia and a splenomegaly, it was possible to induce and observe a marked contraction of the spleen by the intravenous injection of liver extract and the intramuscular injection of adrenalin, hista-mine, and eserine. Accompanying these induced splenic contractions, were marked increases in the number of cellular elements of the circulating blood. The relative proportion of the various cellular components suggests that in the blood of the splenic reservoir the relative proportion of cells is different from that of the circulating blood. These expts. make it obvious that the spleen must be considered as a reservoir not only of red blood cells, but also of proportionally greater numbers of white blood cells and blood platelets.

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