THE ACTION OF COMMONLY USED ANTIEMETICS ON THE LOWER OESOPHAGEAL SPHINCTER

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Abstract
The effects of five antiemetic drugs on the lower oesophageal sphincter (LOS) were studied in five groups, each comprising eight healthy volunteers. Cyclizine, prochlorperazine and metoclopramide have a desirable functional effect on LOS, while promethazine and droperidol were associated with evidence of increased gastro—oesophageal reflux.